Abstract

Case Report

Hepatic adenomatosis: A clinically challenging rare liver disease

Sunitha Ramachandra*, Lakshmi Rao and Masoud Al Kindi

Published: 11 July, 2018 | Volume 2 - Issue 1 | Pages: 005-008

43-year-old lady presented with incidentally discovered liver lesions while she was being managed for her complaints of menorrhagia. CT and MRI showed hepatomegaly with multiple lesions in both lobes of the liver with vascular element in the background of diffuse fatty infiltration. Patient underwent laparoscopic core biopsy. Histopathology showed extensive steatosis, intracytoplasmic giant mitochondria and absence of portal tracts, features highly suggestive of hepatic adenomatosis. IHC staining showed membranous and cytoplasmic positivity in hepatocytes for B-catenin consistent with multiple hepatic adenomatosis. Hepatic adenomatosis is a new clinical entity in the hepatological practice characterized by the presence of 10 or more nodules in the liver known for its major complication of bleeding. Hepatic adenomatosis is managed by regular imaging and resection of large (> 5cm) superficial and painful adenomas along with liver function tests and tumor markers to rule out malignant transformation. However, the potential cure being the liver transplantation.

Read Full Article HTML DOI: 10.29328/journal.acgh.1001006 Cite this Article Read Full Article PDF

References

  1. Barthelmes L, Tait I. Liver cell adenoma and liver cell adenomatosis. HPB. 2005; 7:186-196. Ref.: https://tinyurl.com/yboxbcdc
  2. Donato M, Jahromi AH, Andrade A, Kim R, Chaudhery SI, et al. Hepatic Adenomatosis: A rare but important liver disease with severe clinical implications. Int Surg. 2015; 100: 903-907. Ref.: https://tinyurl.com/ybhb6xbr
  3. Geller SA, Petrovic LD. Tumour and tumour-like conditions. In: Biopsy Interpretation of the Liver. 2nd edition. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins. 2009; 318.
  4. Chiche L, Dao T, Salamé E, Galais MP, Bouvard N, et al. Liver Adenomatosis: Reappraisal, Diagnosis, and Surgical Management: Eight New Cases and Review of the Literature. Ann Surg. 2000; 231: 74-81. Ref.: https://tinyurl.com/ybgbxrc6

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