Research Article
Biomarkers in Enteropathic Arthritis
Luis Arturo Gutiérrez-Gonzalez*, Eillen Macias, Freddy Herrera-Vivas, Franz Otaiza, Juan Carlos Gonzalez Duran and Guillermo Veitia
Published: 04 June, 2020 | Volume 4 - Issue 1 | Pages: 039-044
Inflammatory Bowel Disease (IBD)-associated arthritis is called Enteropathic Arthritis (EA) which is classified among the group of Spondyloarthritis (SpA), because its presentation is variable. The current trend is to classify them as autoinflammatory rather than autoimmune diseases, since no antibodies have yet been identified. The study of biomarkers (BM) will help us with early identification and hence, to provide treatment in the early stages, prior to radiographic progression, which will enable prompt identification of the disease phenotype. 42 patients diagnosed with IBD were included, of which 48% were females; the mean age of the study group was 48.12 ± 5.02 (95% CI). The average time of evolution of disease was 37.57 ± 14.28 months; most patients referred to the rheumatologist had a diagnosis of ulcerative colitis (83%). According to our analysis, we were able to determine that the three most significant variables influencing the development of sacroiliitis were: Lactoferrin, ANCA and HLA B27 (p < 0.5). The variable that can be ruled out because of its almost neglectable contribution was fecal calprotectin.
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DOI: 10.29328/journal.acgh.1001021
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Keywords:
Biomarkers; Spondyloarthritis; Inflammatory Bowel Disease; ASCA; ANCA; HLAB-27
References
- Bossuyt X. Serologic markers in inflammatory bowel disease. Clin Chem. 2006; 52: 171-181. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/16339302
- Sandborn WJ. Serologic markers in inflammatory bowel disease: state of the art. Rev Gastroenterol Disord. 2004; 4: 167-174.
- Prideaux L, De Cruz P, Ng SC, Kamm MA. Serological antibodies in infl ammatory bowel disease: a systematic review. Infl amm Bowel Dis. 2012; 18: 1340-1355. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/22069240
- Abadi I, Gonzalez L, Paul H, Grases P, Pérez G, et al. Silent colonic findings in seronegative spondyloarthropathies. Rev Rheumat. 1981; 11: 119.
- Dougados M, Van der Linden S, Juhlin R, Huitfeldt B, Amor B, et al. The European Spondylarthropathy Study Group preliminary criteria for the classification of spondylarthropathy. Arthritis Rheum. 1991; 34: 1218-1227.
- Saxon A, Shanahan F, Landers C, Ganz T, Targan S. A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease. J Allergy Clin Immunol. 1990; 86: 202-210. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/2200820
- Rump JA, Scholmerich J, Gross V, Roth M, Helfesrieder R, et al. A new type of perinuclear anti-neutrophil cytoplasmic antibody (p-ANCA) in active ulcerative colitis but not in Crohn’s disease. Immunobiology. 1990; 181: 406–413. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/2099908
- Zhou G, Song Y, Yang W, Guo Y, Fang L, et al. ASCA, ANCA, ALCA and Many More: Are They Useful in the Diagnosis of Inflammatory Bowel Disease?. Dig Dis. 2016; 34: 90-97.
- Homsak E, Micetic-Turk D, Bozic B. Autoantibodies pANCA, GAB and PAB in infl ammatory bowel disease: prevalence, characteristics and diagnostic value. Wien Klin Wochenschr. 2010; 122(Suppl 2): 19-25. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/20517666
- Rudwaleit M, Baeten D. Ankylosing spondylitis and bowel disease. Best Pract Res Clin Rheumatol. 2006; 20: 451-471. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/16777576
- Austin GL, Herfarth HH, Sandler RS. A critical evaluation of serologic markers for inflammatory bowel disease. Clin Gastroenterol Hepatol. 2007; 5: 545-547. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/17433787
- Desplat-Jégo S, Johanet C, Escande A, Goetz J, Fabien N, et al. Update on anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicenter study, World J Gastroenterol. 2007; 13: 2312-2318. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/17511029
- Austin GL, Shaheen NJ, Sandler RS. Positive and negative predictive values: Use of inflammatory bowel disease serologic markers. Am J Gastroenterol. 2006; 101: 413-416. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/16542272
- Mendoza JL, Abreu MT. Biological markers in inflamatory bowel disease: Practical consideration for clinicians. Gastroenterol Clin Biol. 2009; 33(Suppl 3): S158-173. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/20117339
- Reumaux D, Sendid B, Poulain D, Duthilleul P, Dewit O, et al. Serological markers in inflammatory bowel diseases. Best Pract Res Clin Gastroenterol. 2003; 17: 19–35. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900099/
- Danese S, Papa A, Saibeni S, Repici A, Malesci A, et al. Inflammation and coagulation in inflammatory bowel disease: The clot thickens. Am J Gastroenterol. 2007; 102: 174-186. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/17100967
- Paredes JM, Barrachina MM, Roman J, Moreno-Osset E. Patología articular en la enfermedad inflamatoria intestinal. Gastroenterol Hepatol. 2005; 28: 240-249.
- Danese S, Semeraro S, Papa A, Roberto I, Scaldaferri F, et al. Extraintestinal manifestations in inflammatory bowel disease. World J Gastroenterol. 2005; 11: 7227-7236. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/16437620
- Aydin SZ, Maksymowych WP, Bennett AN, McGonagle D, Emery P, et al. Validation of the ASAS criteria and definition of a positive MRI of the sacroiliac joint in an inception cohort of axial spondyloarthritis followed up for 8 years. Ann Rheum Dis. 2012; 71: 56-60. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/21900284
- Weber U, Lambert RGW, Østergaard M, Hodler J, Pedersen SJ, et al. The diagnostic utility of magnetic resonance imaging in spondyloarthritis. An international multicenter evaluation of one hundred eighty-seven subjects. Arthritis Rheum. 2010; 62: 3048-3058. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/20496416
- Conigliaro P., et al. Impact of a multidisciplinary approach in enteropathic spondyloarthritis patients. Autoimmunity Reviews. 2016 Feb;15(2):184-90.
- Gutierrez-Gonzalez LA, Nuñez-Sotelo CM, Gonzalez N, Losada BR. High level CTx-II in early Spondyloarthritis patients. Rev Argent Reumatol. 2007; 18: 2.
- Sarzi-Puttini, Ardizzone S, Manzionna G, et al. Infliximab-induced lupus in Crohn’s disease: a case report. Dig Liver Dis. 2003; 35: 814–817. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/14674674
- Hanauer SB, Feagan BG, Lichtenstein GR, Mayer LF, Schreiber S, et al. ACCENT I Study Group. Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial. Lancet. 2002; 35: 1541–1549. PubMed: https://pubmed.ncbi.nlm.nih.gov/12047962
- Hanauer S, Sandborn W, Rutgeerts P, Fedorak RN, Lukas M, et al. Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn’s disease: the CLASSIC-I trial. Gastroenterology. 2006; 130: 323–333. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/16472588
- Rutgeerts P, Sandborn WJ, Feagan BG, et al. Infliximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med. 2005; 353: 2462–2476. PubMed: https://pubmed.ncbi.nlm.nih.gov/16339095
- Sandborn WJ, Feagan BG, Stoinov S, Honiball PJ, et al. PRECISE 1 Study Investigators. Certolizumab pegol for the treatment of Crohn’s disease. N Engl J Med. 2007; 357: 228–238. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/17634458
- Kolho KL, Raivio T, Lindahl H, Savilahti E. Fecal calprotectin remains high during glucocorticoid therapy in children with inflammatory bowel disease. Scand J Gastroenterol. 2006; 41: 720-725. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/16716972
- Bonnin Tomás A, Vila Vidal M, Rosell Camps A. Calprotectina fecal como marcador diferencial entre patología gastrointestinal orgánica y funcional. Rev Esp Enferm Dig. 2007; 99: 689-693.
- Arai R. Serologic markers: impact on early diagnosis and disease stratification in infl ammatory bowel disease. Postgrad Med. 2010; 122: 177-185. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/20675980
- Riis L, Vind I, Vermeire S, Wolters F, Katsanos K, Politi P, et al. The prevalence of genetic and serologic markers in an unselected European population-based cohort of IBD patients. Infl amm Bowel Dis. 2007; 13: 24–32. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/17206636
- Grzybowska-Chlebowczyk U, Wos H, Sieron AL, Wiecek S, Augusciak-Duma A, et al. Serologic investigation in children with infl ammatory bowel disease and food allergy. Mediators Inflamm. 2009; 5126195. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796464/
- Basta Z, Csi I, Szabo G, Szegedi G. Seroreactovity against Saccharomyces cerevisiae in patients with Crohn’s disease and celiac disease. World J Gastroenterol. 2003; 9: 2380–2412. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656483/
- Eriksson C, Engstrand S, Sundqvist KG, Rantapää-Dahlqvist S, et al. Autoantibody formation in patients with rheumatoid arthritis treated with anti-TNF. Ann Rheum Dis. 2005; 64: 403–407. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/15297281
- Nakamura RM, Matsutani M, Barry M. Advances in clinical laboratory tests for inflammatory bowel disease. Clin Chim Acta. 2003; 335: 9-20. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/12927679
- Picchianti-Diamanti A, Lorenzetti R, Chimenti MS , Luchetti MM, Conigliaro P, et al. Enteropathic spondyloarthritis: Results from a large nationwide database analysis. Autoimmunity Reviews. 2020; 19: 102457. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/31838160
- Beigel F, Ju¨rgens M, Tillack C, Subklewe M, Mayr D, et al. Hepatosplenic T-cell lymphoma in a patient with Crohn’s disease. Nat Rev Gastroenterol Hepatol. 2009; 6: 433–436. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/19575026
- Talwalkar JA, Lindor KD. Primary sclerosing cholangitis. Inflamm Bowel Dis. 2005; 11: 62-72. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/15674115
- García-Planella E, Domènech E. Osteopenia y osteoporosis en la enfermedad inflamatoria intestinal. Gastroenterol Hepatol. 2004; 27: 417-424.
- Mintz R, Feller ER, Bahr RL, Shah SA. Ocular manifestations of inflammatory bowel disease. Inflamm Bowel Dis. 2004; 10: 135-139. PubMed: https://pubmed.ncbi.nlm.nih.gov/15168814
- Rothfuss KS, Stange EF, Herrlinger KR. Extraintestinal manifestations and complications in inflammatory bowel diseases. World J Gastroenterol. 2006; 12: 4819- 4831. PubMed: https://pubmed.ncbi.nlm.nih.gov/16937463
- Storch I, Sachar D, Katz S. Pulmonary manifestations of inflammatory bowel disease. Inflamm Bowel Dis. 2003; 9: 104-115. PubMed: https://pubmed.ncbi.nlm.nih.gov/12769444
- Trost LB, McDonell JK. Important cutaneous manifestations of inflammatory bowel disease. Postgrad Med J. 2005; 81: 580-585. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/16143688
- Tsianos EV, Katsanos K. Do we really understand what immunological disturbances in inflammatory bowel disease mean? World J Gastroenterol. 2009; 15: 521-555.